Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for therapeutics. Among them, the Y220C mutation is the ninth most frequent and it ...

A study demonstrates that the 'previous state' of blood stem cells plays a decisive role in the subtype of leukemia that develops. The new technique, called STRACK, allows monitoring of the evolution ...

Functioning brain cells need a functioning system for picking up the trash and sorting the recycling. But when the cellular ...

Knowing which lysosomal proteins are enriched in which brain cell types will help better understand contribution to neurological disorders.

Using cortical organoids from individuals with autism, researchers tracked gene activity over development. Early ...

Researchers have pinpointed what could be the early genetic origins of breast cancer -- cancer-like mutations appearing in the cells of healthy women. In a new study, the international collaborators ...

A common mutation in the KRAS gene is associated with improved overall survival in pancreatic ductal adenocarcinoma (PDAC) compared with other variants, in part because the mutation appears to lead to ...

Histamine is widely known for its role in allergic reactions but also functions as a key neurotransmitter in the brain, where ...

Deafness, the most common sensorineural hearing loss at all stages of life, occurs either independently or as part of syndromes associated with other symptoms, such as Usher syndrome type 1. In a ...

Biological aging undeniably affects human cognitive function. 1 However, how this happens—the underlying factors, interactions, and processes—remains unclear. He and his team want to understand how ...